Semaglutide

Description

Semaglutide is a synthetic analogue of human glucagon-like peptide-1 in which an aminoisobutyric acid substitution and a C18 fatty diacid side chain are used to slow enzymatic degradation and increase albumin binding. It is one of the most widely cited reference peptides in GLP-1 receptor research.

Product Specifications

• Compound: Semaglutide
• Class: Synthetic 31-amino-acid GLP-1 analogue
• Sequence: GLP-1(7-37) analogue with Aib substitution at position 8 and a C18 fatty diacid side chain
• Molecular weight: ~4114 Da
• CAS number: 910463-68-2
• Form: Lyophilised powder in a sealed glass vial
• Available sizes: 20 mg per vial
• Purity: ≥99% by HPLC — see the certificate of analysis for the batch supplied

Research Background

Semaglutide is used as a comparator and reference standard across incretin research. Literature topics include:

• GLP-1 receptor binding and cAMP accumulation assays
• DPP-4 resistance conferred by Aib substitution
• Albumin binding and half-life extension chemistry
• Comparative studies against native GLP-1 and other analogues

Peer-reviewed literature on this compound can be searched through PubMed and the NIH PMC database. Troy Peptides supplies reference material only and does not provide research protocols or interpret published findings.

Analytical Verification

Identity and purity are confirmed by independent third-party analysis before release.

• High-performance liquid chromatography (HPLC) for purity quantification
• Mass spectrometry (MS) for identity and molecular weight confirmation

A third-party certificate of analysis is available for every product. See Certificates of Analysis.

Handling and Storage

• Lyophilised material: store cool, dry and away from direct light; −20 °C for long-term storage
• After reconstitution: refrigerate at 2–8 °C and protect from light
• Avoid repeated freeze–thaw cycles

Terms of Sale

This product is supplied strictly for in vitro laboratory research. It is not a drug, food or cosmetic, has not been evaluated by the FDA, and is not intended to diagnose, treat, cure or prevent any disease. By purchasing, the buyer confirms that they are at least 21 years of age and a qualified research professional or institution, and that this material will not be used for human consumption, veterinary use or any in vivo application.