MOTS-c

Description

MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S ribosomal RNA gene rather than the nuclear genome. That unusual origin is what put it at the centre of research into mitochondrial-derived peptides and retrograde signalling between mitochondria and the nucleus.

Product Specifications

• Compound: MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c)
• Class: Mitochondrial-derived peptide (16 amino acids)
• Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
• Molecular weight: ~2174 Da
• CAS number: 1627580-64-6
• Form: Lyophilised powder in a sealed glass vial
• Available sizes: 10 mg per vial
• Purity: ≥99% by HPLC — see the certificate of analysis for the batch supplied

Research Background

MOTS-c is studied as a model mitochondrial-derived peptide. Topics include:

• AMPK pathway activation in cultured cells
• Folate and methionine cycle metabolomics
• Mitochondrial-to-nuclear retrograde signalling
• Expression profiling across tissue and age models

Peer-reviewed literature on this compound can be searched through PubMed and the NIH PMC database. Troy Peptides supplies reference material only and does not provide research protocols or interpret published findings.

Analytical Verification

Identity and purity are confirmed by independent third-party analysis before release.

• High-performance liquid chromatography (HPLC) for purity quantification
• Mass spectrometry (MS) for identity and molecular weight confirmation

A third-party certificate of analysis is available for every product. See Certificates of Analysis.

Handling and Storage

• Lyophilised material: store cool, dry and away from direct light; −20 °C for long-term storage
• After reconstitution: refrigerate at 2–8 °C and protect from light
• Avoid repeated freeze–thaw cycles

Terms of Sale

This product is supplied strictly for in vitro laboratory research. It is not a drug, food or cosmetic, has not been evaluated by the FDA, and is not intended to diagnose, treat, cure or prevent any disease. By purchasing, the buyer confirms that they are at least 21 years of age and a qualified research professional or institution, and that this material will not be used for human consumption, veterinary use or any in vivo application.