Description
SS-31 is a four-residue peptide with an alternating aromatic-cationic motif that causes it to concentrate at the inner mitochondrial membrane, where it associates with cardiolipin. Its D-arginine residue and dimethylated tyrosine make it notably resistant to peptidase degradation.
Product Specifications
- Compound: SS-31 (elamipretide)
- Class: Synthetic mitochondria-targeting tetrapeptide
- Sequence: D-Arg-2,6-dimethyl-Tyr-Lys-Phe-NH2
- Molecular weight: ~639.8 Da
- CAS number: 736992-21-5
- Form: Lyophilised powder in a sealed glass vial
- Available sizes: 10 mg per vial
- Purity: ≥99% by HPLC — see the certificate of analysis for the batch supplied
Research Background
SS-31 is a standard tool compound in mitochondrial research. Topics include:
- Cardiolipin binding and inner membrane association
- Electron transport chain efficiency in isolated mitochondria
- Reactive oxygen species generation assays
- Cristae morphology and membrane curvature studies
Peer-reviewed literature on this compound can be searched through PubMed and the NIH PMC database. Troy Peptides supplies reference material only and does not provide research protocols or interpret published findings.
Analytical Verification
Identity and purity are confirmed by independent third-party analysis before release.
- High-performance liquid chromatography (HPLC) for purity quantification
- Mass spectrometry (MS) for identity and molecular weight confirmation
A third-party certificate of analysis is available for every product. See Certificates of Analysis.
Handling and Storage
- Lyophilised material: store cool, dry and away from direct light; −20 °C for long-term storage
- After reconstitution: refrigerate at 2–8 °C and protect from light
- Avoid repeated freeze–thaw cycles
Terms of Sale
This product is supplied strictly for in vitro laboratory research. It is not a drug, food or cosmetic, has not been evaluated by the FDA, and is not intended to diagnose, treat, cure or prevent any disease. By purchasing, the buyer confirms that they are at least 21 years of age and a qualified research professional or institution, and that this material will not be used for human consumption, veterinary use or any in vivo application.
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