IGF-1 LR3

Description

IGF-1 LR3 is a recombinant analogue of human insulin-like growth factor-1 carrying two modifications: an arginine substitution at position three and a thirteen-residue N-terminal extension. Both changes sharply reduce binding to IGF binding proteins, which is why it is favoured as a supplement in serum-free cell culture media.

Product Specifications

• Compound: IGF-1 LR3 (Long R3 insulin-like growth factor-1)
• Class: Recombinant 83-amino-acid protein analogue
• Sequence: IGF-1 with Arg substituted at position 3 and a 13-residue N-terminal extension
• Molecular weight: ~9111 Da
• CAS number: 946870-92-4
• Form: Lyophilised powder in a sealed glass vial
• Available sizes: 1 mg per vial
• Purity: ≥99% by HPLC — see the certificate of analysis for the batch supplied

Research Background

IGF-1 LR3 is used widely in cell culture and receptor research. Topics include:

• Serum-free and low-serum cell culture supplementation
• IGF-1 receptor binding and downstream PI3K/Akt signalling
• IGF binding protein interaction studies
• Comparative potency against native IGF-1

Peer-reviewed literature on this compound can be searched through PubMed and the NIH PMC database. Troy Peptides supplies reference material only and does not provide research protocols or interpret published findings.

Analytical Verification

Identity and purity are confirmed by independent third-party analysis before release.

• High-performance liquid chromatography (HPLC) for purity quantification
• Mass spectrometry (MS) for identity and molecular weight confirmation

A third-party certificate of analysis is available for every product. See Certificates of Analysis.

Handling and Storage

• Lyophilised material: store cool, dry and away from direct light; −20 °C for long-term storage
• After reconstitution: refrigerate at 2–8 °C and protect from light
• Avoid repeated freeze–thaw cycles

Terms of Sale

This product is supplied strictly for in vitro laboratory research. It is not a drug, food or cosmetic, has not been evaluated by the FDA, and is not intended to diagnose, treat, cure or prevent any disease. By purchasing, the buyer confirms that they are at least 21 years of age and a qualified research professional or institution, and that this material will not be used for human consumption, veterinary use or any in vivo application.